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The Science Behind CortiSLIM

CortiSLIM (R) three proprietary complexes

CortiSLIM Original provides a unique three-pronged approach to weight loss by addressing stress, enhancing thermogenesis (so you can burn more fat) and encouraging lean body mass through supporting healthy blood glucose levels. This revolutionary product blends three Proprietary Complexes in its unique and powerful weight loss formula to give you The CortiSLIM Advantage!

1. CortiPlex® Complex

The CortiPlex® Complex, in CortiSLIM Original and Advanced, combines a host of natural calming ingredients to compliment the stress-reducing effects of exercise.* Reducing stress is an important component to weight loss as preliminary studies1 suggest that stress may be responsible for elevated levels of the steroid hormone, Cortisol (also known as the "stress hormone") and may be associated with increased appetite and weight gain. Regular exercise is one of the best ways to maintain healthy stress levels.

Cortisol is a necessary component in the human body as it assists you in regulating blood pressure, cardiovascular function, and your body's use of fats, proteins and carbohydrates. Cortisol is also involved in such important functions as glucose metabolism, insulin release for blood sugar maintenance, and inflammatory response. Research2 indicates that under normal circumstances, your body maintains or regulates your natural Cortisol levels. For example, most healthy adults have a higher Cortisol level first thing in the morning and a lower Cortisol level at night. But when you're under stress, your body secretes more Cortisol, which is why it is often called the "stress hormone." Small increases of Cortisol often produce positive side effects like improved memory, reduced sensitivity to pain, and rapid bursts of energy. But elevated Cortisol levels, or excessive Cortisol in the bloodstream, due to such things as prolonged or chronic stress, can cause negative side effects such as suppression of thyroid function, cognitive impairment, increased blood pressure, decreased bone density, and blood sugar imbalances. High levels of Cortisol can also lower your immunity and inflammatory responses, as well as slow down the wound healing process.

Cortisol releases glucose into your bloodstream and increases blood pressure for increased physical activity such as running or fighting. Your brain is stimulated for more intense awareness. Immune system activity is reduced to save energy for physical activity.

Cortisol taps energy from your body's most-easily available sources. Muscle tissue is skimmed to produce glucose for energy. Triglycerides are mobilized from fat tissues. Short-term stressors and even cyclical daily variations cause elevated Cortisol levels that are normal and healthy to provide energy for different activities. Cortisol levels in the blood are usually higher in the morning to provide energy.

When physical activity to solve the stressor is used, the energy components produced by Cortisol are used by muscles, nerves and other tissues. Glucose and triglycerides are consumed by the cells providing activity. When Cortisol levels remain elevated for long periods of time (chronic stress), you may perceive a need for extra calories and over-eating is a common result.

2. LeptiPlex® Complex

Our proprietary LeptiPlex® Complex contains a powerful thermogenic blend of ingredients, including Green Tea Extract and healthy Caffeine to enhance your body's ability to efficiently burn more fat.*

When your body experiences an increase in temperature or energy output it is called "thermogenesis." When thermogenesis occurs within your body it causes the body's metabolism to speed up and increases the need for more energy. In order to support the metabolic increase, your body draws on its stored fat cells for additional energy output, causing you to burn fat. This thermogenic process within the body can be triggered by a number of things, including nutrition, supplements and exercise.


A 1999 clinical study3 on the effects of consuming Green Tea and Caffeine together concluded that the combination has thermogenic properties that cause the body's temperature to increase and promote fat oxidation. It was also concluded that Green Tea Extract may play a role in controlling body composition by activating the thermogenic process and facilitating fat oxidation, or both.

For those CortiSLIM users that are looking for increased thermogenic benefits over what CortiSLIM Original's LeptiPlex Blend provides, CortiSLIM® Burn™ may be safely taken in conjunction with the recommended daily dose of CortiSLIM Original. CortiSLIM® Burn™ is not a 3-complex blend like CortiSLIM Original, rather, it's a powerful thermogenic blend, designed to provide maximum fat burning thermogenic benefits.

CortiSLIM Burn's formula contains added levels of Green Tea Extract and Caffeine, along with other clinically tested ingredients to help trigger thermogenesis within the body. If you're looking for maximum fat burning results, CortiSLIM Burn™ is a great solution for providing added weight loss support!

3. Insutrol® Blend

CortiSLIM’s proprietary Insutrol® blend is made of scientifically tested4 ingredients that have been shown to support healthy blood glucose (sugar) levels*. Maintaining healthy blood glucose (sugar) levels is an important part of weight management and good health. When our bodies produce excess sugar that is not utilized at the cell level, it converts to fat tissue.

Insulin plays a critical role in allowing our cells to absorb glucose molecules for healthy energy. Glucose molecules in our bloodstream can only enter our cells when insulin molecules are effectively received by the insulin receptors. Insulin molecules serve as a "key" to unlock the door allowing glucose to enter the cell to be converted to energy as illustrated below:

normal cell

Comment by Dr. Chappell:

CortiSLIM was specifically formulated to help increase metabolism and normalize cortisol levels. Along with adrenaline and cortisone, excess cortisol is known as one of the stress hormones and is released in abundance during those times. Researchers from UC San Francisco validated that those with increased belly fat had higher levels of cortisol compared to others with less belly fat.

There are plenty of studies to at least suggest a link between central obesity; marked by abdominal fat and a high waist-to-hip ratio and elevated cortisol levels. New studies are produced every week making this correlation.

One such study examined 59 healthy premenopausal women, 30 of whom demonstrated central fat distribution as determined by a high waist-to-hip ratio, and 29 of whom did not. All 59 women participated in three sessions of psychosocial challenges on four consecutive days to gauge and measure their reaction to stress. Women with higher waist-to-hip ratios experienced the laboratory challenges as more threatening, performed more poorly on them, and reported more chronic stress. These women also secreted more cortisol than women with lower waist-to- hip ratios. The investigators noted that central fat distribution is related to greater psychological vulnerability to stress and cortisol reactivity. They then state; “stress-induced cortisol secretion may contribute to central fat.”

In a study published in 2004, researchers examined the relationship between stress levels, cortisol, and abdominal obesity in 22 obese women, 11 of whom had a binge-eating disorder. The researchers found a positive correlation between high stress and cortisol levels and central obesity, noting, “Hyperactive HPA axis due to stress raises cortisol levels which then may contribute to binge eating and abdominal obesity.”

Clearly, there is an intimate relationship between stress, cortisol levels, and overall health. Modulating cortisol levels may thus offer support for healthy weight management and prevent negative health outcomes associated with central obesity, such as type II diabetes.

Here are a couple of scientific references to validate the above statements:

1. Epel ES, McEwen B, Seeman T, et al. Stress and body shape: Stress-induced cortisol secretion is consistently greater among women with central fat. Psychosomatic Med. 2000 Sept; 62(5):623-32.

2. Gluck ME, Geliebter A, Lorence M. Cortisol stress response is positively correlated with central obesity in obese women with binge eating disorder (BED) before and after cognitive-behavioral treatment. Ann NY Acad Sci. 2004 Dec; 1032:202-7.

Cortisol is a necessary hormone, but not unlike other hormones such a testosterone, progesterone, or estrogen, if cortisol is out of balance; in excess, it becomes toxic to the body. The key to CortiSLIM is its ability to bring cortisol back into balance while increasing ones metabolism thus effectuating body fat accumulation, energy levels and more.

According to Nicholas V. Perricone, MD, “When we are under stress, our adrenal glands produce hormones. These include the fight-or-flight hormones, epinephrine (adrenaline) and norepinephrine (noradrenaline), as well as cortisol.”

Cortisol is a glucocorticoid, one of a group of steroid hormones that include cortisone. Cortisol is involved in carbohydrate, protein, and fat metabolism, and has anti-inflammatory properties. As we age, the “youth” hormones such as testosterone, estrogen, and human growth hormone decline. Cortisol, however, increases as we age and too much cortisol can also become pro- inflammatory.

When we experience stress (whether from fear, anxiety, physical or emotional trauma, or overexertion), the stress hormones epinephrine and norepinephrine will return to normal levels as the stress subsides. In a young person, cortisol levels will also return to normal within a few hours. Because cortisol levels continue to rise with age, the older person’s cortisol levels will remain elevated for long periods of time. This has earned cortisol the dubious distinction of being known as a “death” hormone, because high levels of cortisol exert a catabolic or muscle-wasting, deteriorating action on the body. Simply put, it breaks down tissue.

How Stress Promotes Weight Gain

Cortisol stimulates fat and carbohydrate metabolism for fast energy (the fight-or-flight response), thereby stimulating insulin release to keep pace with the rising blood sugar levels. This results in an increase in our appetite. If we experience chronic stress, with chronically high levels of cortisol, we may end up hungry all the time, causing us to overeat.

Cortisol also influences where that weight will be deposited. A fascinating study on the effects of the release of cortisol during acute and chronic stress in non- overweight women was published in the journal Psychosomatic Medicine in 2001. The study clearly demonstrated that this excess cortisol contributes to the deposition of visceral fat, particularly in the abdominal region.

As we know, there are two types of fat: subcutaneous (under the skin) and visceral (found in the abdomen and surrounding our vital organs).

Central obesity sets the stage for a host of health concerns such as heart disease, strokes, and diabetes. Because of its serious threat to health, this has also been referred to as “toxic fat.” Traditionally, women worried about the size of their hips. However, when it comes to overall weight gain, it is preferable to have it on the hips as opposed to the stomach area—if not from an aesthetic point of view, then from a health point of view. Studies indicate that women (and men) who store their weight in the abdominal area have higher cortisol levels and higher stress levels than those whose weight is stored on the hips.

Visceral fat is metabolized by the liver, which turns it into cholesterol that circulates in the blood. This is the so-called “bad” cholesterol, low-density lipoprotein or LDL, which collects in the arteries forming plaque (deposits of fats, inflammatory cells, proteins, and calcium material along the lining of arteries). The plaque builds up and narrows the artery, resulting in atherosclerosis. Researchers have also found that consuming a lot of saturated fats such as butter and the fats found in red meats can lead to the accumulation of visceral fat. The high omega-3 content found in wild Alaskan salmon, anchovies, sardines, and other cold-water fish, along with fish oil capsules, will help you to get rid of this deadly form of fat because the essential fatty acids found in these foods can decrease cortisol levels.”

There is plenty of research to show the connection/link of excess cortisol levels and fat. To sum up, elevated cortisol levels produce a host of negative effects that include:

• increased inflammation

• increased insulin secretion

• increased appetite

• storage of fat, particularly in the abdomen

• Increased risk of acne flare-ups.

• Acne is an inflammatory disease and stress precipitates and aggravates acne breakouts.

• The death of brain cells. High levels of stress actually shrink the brain and other organs.

• destruction of the immune system

• decreased muscle mass

• Accelerated aging

Although the new, advanced CortiSLIM has over a dozen ingredients all designed to increase energy, nourish the body and help support normal cortisol levels thereby helping to reduce excess body fat, here are just two ingredients found in CortiSLIM and their known health benefits:


Chromium is a critical nutrient in our effort to control and reduce excess body fat. By supplementing our diets with chromium, we can effectively lower blood sugar and insulin levels; the key to an anti-inflammatory weight-loss diet. One reason people are overweight is because they’re in an inflammatory state that has put a “lock” on their fat-burning mechanism. Chromium helps decrease inflammation, thereby unlocking the enzymes that aid in fat metabolization.

Chromium not only affects blood sugar and insulin levels, it can also help normalize blood lipids such as triglycerides and cholesterol, increasing levels of the HDL “good” cholesterol and lowering total cholesterol and triglycerides, making it cardio-protective.

Experts in the field of nutrition report that the general population of the United States is deficient in chromium and low levels of chromium are associated with type II diabetes and cardiovascular disease. Studies have also been published noting that increased consumption of sugar depletes our body stores of chromium, placing us at further risk for hyperglycemia and hyper-insulinemia (too much blood sugar, too much insulin).

Chromium Tips

• Chromium is an essential nutrient required for normal sugar and fat metabolism.

• Chromium is important for energy production, and also plays a key role in regulating appetite, reducing sugar cravings, and lowering body fat.

• Chromium absorption is made more difficult when milk, as well as foods high in phosphorus, are eaten at the same time.

• Don’t take chromium with foods rich in phytic acid (unleavened bread, raw beans, seeds, nuts, grains, and soy isolates) as this may decrease its absorption.

• The recommended type of this supplement is chromium polynicotinate which is found in CortiSLIM.

Alpha Lipoic Acid

Alpha Lipoic Acid is a potent antioxidant and anti-inflammatory. It is found naturally in the body, locked inside the mitochondria. Lipoic acid is part of an enzyme complex called the pyruvate dehydrogenase complex, making it intimately involved in the energy production of the cell. Alpha Lipoic Acid enhances our ability to metabolize food into energy.

Unlike many other antioxidants such as vitamin C, which is strictly water soluble, or vitamin E, which is strictly fat soluble, Alpha Lipoic Acid is soluble in both water and fat. This means that Alpha Lipoic Acid can go to all parts of the cell, including the lipid (fat) portions such as the cell plasma membrane, as well as the interior of the cell (known as the cytoplasm) where water- soluble chemicals reside. Because of this unique property, Alpha Lipoic Acid is often referred to as “the universal antioxidant.”

On a cellular level, Alpha Lipoic Acid exerts a wide variety of positive actions, all of them anti- inflammatory. It also blocks the activation of transcription factor NfkB as well, if not better than, any other antioxidant/anti-inflammatory thus far discovered.

In addition to its function as a powerful antioxidant/anti-inflammatory, Alpha Lipoic Acid increases the body’s ability to take glucose into the cells. This insulin-sensitizing effect is also seen in some of the other nutrients that we have discussed. These nutrients all work synergistically to increase sensitivity to insulin, resulting in decreased blood sugar levels. Alpha Lipoic Acid is also very powerful in preventing glycation.

Alpha Lipoic Acid Tips

• In the metabolic cycle, Alpha Lipoic Acid acts as a coenzyme in the production of energy by converting carbohydrates into energy (ATP).

• Alpha Lipoic Acid is the only antioxidant that can boost cellular levels of glutathione, the body’s most important antioxidant to overall health and longevity.

Dr. Legome took 40 overweight, stressed out patients and using saliva cortisol levels; proved cortisol levels were reduced along with weight reduction; fat loss and a reduction in excess insulin levels. Simply, by taking CortiSLIM; his patients reduced body fat, specifically “belly” fat and reduced their anxiety and other stress indicators.

Comparing synephrine found in bitter orange peel to ephedra, as if ephedra is dangerous because our illustrious FDA banned it.

What is Ephedra?

In China, Ephedra has been used over 2000 years in herbal medicine to treat bronchial asthma, the cold, flu, wheezing, and edema. Plants were and still are collected in autumn, sun-dried, and sectioned. Before use, the sections are boiled, often in a honey-water mixture, and usually further roasted until the water is evaporated. The bitter remedy resulting is prescribed for typhoid, colds, coughing, and various pains.

The dried stems of the species Ephedra geradiana have long been used in Northern India and Pakistan to relieve bronchial asthma. This species is believed to contain the same adrenergic drug similar to ephedrine, which is extracted from other species of the Ephedracea, and used as a bronchodilator in orthodox medicine.

Stem decoctions of Ephedra antisyphilitica in West Texas and Northern Mexico were used to cure renal diseases of the Southwestern American Indians. The seeds of E. nevadensis were also used to alleviate urogenital diseases; the medicine was prepared by roasting and then grinding the seeds into flour.

Like coffee and tea, Ephedra has also been brewed into a beverage and consumed for its stimulant effects. Ma huang extract, from Ephedra sinica and E. equisetina, is made by the same process as instant coffee, and similarly concentrated, with about three times the alkaloid as Ephedra herb.

Mormon tea (Desert tea, Teamster tea) was a very popular stimulant beverage made by the early settlers in the Southwestern United States and Mexico, brewed from the branches of Ephedra trifurca.

FDA Ban of Ephedra

As herbs continue to be in direct competition with the pharmaceutical cartels for every consumer dollar, it was alleged that three people died after a heat stroke and taking an herbal remedy with ephedra in it. There was never any proof ephedra had anything to do with heat stroke. The FDA was under orders to “get rid of ephedra, proof or no proof.”

There are over 486,000 known deaths per year from smoking tobacco. The FDA not only does nothing about it, our government subsidizes the tobacco industry! Ephedra was banned for political and economic reasons. This effective herb is still used throughout the world with little to no adverse effects. So what is synephrine?


Synephrine is an alkaloid found in fruits and vegetables, specifically in Bitter Oranges. An alkaloid is a pharmacologically active class of nitrogen-containing chemical compounds. The confusion many so-called “researchers” have concerning synephrine is not understanding the P form; Para verses the ‘M’ form or Meta. Bitter Orange contains the P form which has only been associated with ONE ADVERSE EVENT out of hundreds of years of use throughout the world.

For a more comprehensive understanding of synephrine, please go to the 28 page article written by Mark Blumenthal, founder and executive director of the American Botanical Council:


The bottom line is neither ephedra nor synephrine are dangerous when taken within safe limits established by hundreds of years of use. Even though a fresh bitter orange contains 270 mg of synephrine per 4 ounces, CortiSLIM contains only 20 mg of synephrine (Bitter Orange Peel) per capsule.

You can reduce cortisol by reducing stress and through a relaxing massage, a walk in the woods, meditating, bike ride, swimming or other activity. As far as being cheaper “than any pricy pill, powder, or capsule marketed”, one massage will pay for a three months’ supply of CortiSLIM. If you are like most people, you can’t always eat properly, exercise or even de-stress.

For those that need a little help, CortiSLIM seems to be the answer.

Try it for yourself and then decide.

*Dr. James Chappell is a retired board certified chiropractic doctor, traditional naturopath, clinical nutritionist and medical herbalist. Since 1971, he has been an avid health researcher and educator specializing in incorporating natural healing protocols for chronic, severe and so-called “terminal” illnesses. As a clinician, he has consulted over 11,000 patients and spent over ten years as one of the "lot" doctors for Paramount, Universal, MGM and Burbank studios in Hollywood, California seeing actors, producers and directors. He is a best-selling author, lecturer, key note speaker, TV and radio personality with 24 TV infomercials, Commissioner – Citizens Commission for Human Rights (CCHR), spokesperson for the Whole Wellness Club, nutraceutical, botanical and aquaceutical formulator, corporate medical consultant and president of Chappell Health Products.

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CortiSlim Advanced NEW with Vitamin D3 with clinically tested Cinnulin PF, CORTISLIM® Advanced. The Lifestyle Answer!, Advanced 3-Complex Weight Loss Formula* Supports Body Fat Reduction*‡ Supports Enhanced Body Composition*‡ Supports Increases in Lean Body Mass* Helps Increase Metabolism* May Support Healthy Glucose Regulation* May Assist in Maintaining Healthy Blood Pressure* ‡ in conjunction with diet and exercise 90 Capsules - Dietary Supplement CortiSlim Burn with Raspberry Ketone
NEW and IMPROVED FORMULA with clinically tested Razberi-K™ (Raspberry Ketone), CORTISLIM® Burn™. Feel the Energy! Fat Burning Weight Loss Formula*
Clinically Tested to Burn More Fat after Exercise*
Helps Increase Metabolism*
Improves Energy and Stamina*
Provides Powerful Antioxidant Protection*
Safe to Use with Other CortiSlim® Products for Added Weight Loss Benefits*
72 Capsules - Dietary Supplement
CortiSlim Original
NEW and IMPROVED FORMULA with clinically tested Cinnulin PF®, CORTISLIM® Original. The Lifestyle Answer!,
3-Complex Weight Loss Formula*
Supports Body Fat Reduction*‡
Supports Enhanced Body Composition*‡
Supports Increases in Lean Body Mass*
Helps Increase Metabolism*
May Support Healthy Glucose Regulation*
May Assist in Maintaining Healthy Blood Pressure*
‡ in conjunction with diet and exercise
90 Capsules - Dietary Supplement