Cortislim and the Stress Hormone Cortisol

CortiSLIM and the Stress Hormone Cortisol

The Nature of Cortisol

CortiSLIM is specifically formulated to help increase metabolism and normalize cortisol levels. Along with adrenaline and cortisone, excess cortisol is known as one of the stress hormones and is released in abundance during those times. Researchers from UC San Francisco validated that those with increased belly fat had higher levels of cortisol compared to others with less belly fat.

There are plenty of studies to at least suggest a link between central obesity; marked by abdominal fat and a high waist-to-hip ratio and elevated cortisol levels. New studies are produced every week making this correlation.

One such study examined 59 healthy premenopausal women, 30 of whom demonstrated central fat distribution as determined by a high waist-to-hip ratio, and 29 of whom did not. All 59 women participated in three sessions of psychosocial challenges on four consecutive days to gauge and measure their reaction to stress. Women with higher waist-to-hip ratios experienced the laboratory challenges as more threatening, performed more poorly on them, and reported more chronic stress. These women also secreted more cortisol than women with lower waist-to-hip ratios. The investigators noted that central fat distribution is related to greater psychological vulnerability to stress and cortisol reactivity. They then state; “stress-induced cortisol secretion may contribute to central fat.”

In a study published in 2004, researchers examined the relationship between stress levels, cortisol, and abdominal obesity in 22 obese women, 11 of whom had a binge-eating disorder. The researchers found a positive correlation between high stress and cortisol levels and central obesity, noting, “Hyperactive HPA axis due to stress raises cortisol levels which then may contribute to binge eating and abdominal obesity.”

Clearly, there is an intimate relationship between stress, cortisol levels, and overall health. Modulating cortisol levels may thus offer support for healthy weight management and prevent negative health outcomes associated with central obesity, such as type II diabetes.

Cortisol is a necessary hormone, but not unlike other hormones such a testosterone, progesterone, or estrogen, if cortisol is out of balance and in excess, it becomes toxic to the body. The key to CortiSLIM is its ability to bring cortisol back into balance while increasing ones metabolism, thus effectuating body fat accumulation, energy levels and more.

According to Nicholas V. Perricone, MD, “When we are under stress, our adrenal glands produce hormones. These include the fight-or-flight hormones, epinephrine (adrenaline) and norepinephrine (noradrenaline), as well as cortisol.

Cortisol is a glucocorticoid, one of a group of steroid hormones that include cortisone. Cortisol is involved in carbohydrate, protein, and fat metabolism, and has anti-inflammatory properties. As we age, the “youth” hormones such as testosterone, estrogen, and human growth hormone decline. Cortisol, however, increases as we age and too much cortisol can also become pro-inflammatory.

When we experience stress (whether from fear, anxiety, physical or emotional trauma, or overexertion), the stress hormones epinephrine and norepinephrine will return to normal levels as the stress subsides. In a young person, cortisol levels will also return to normal within a few hours. Because cortisol levels continue to rise with age, the older person’s cortisol levels will remain elevated for long periods of time. This has earned cortisol the dubious distinction of being known as a “death” hormone, because high levels of cortisol exert a catabolic or muscle-wasting, deteriorating action on the body. Simply put, it breaks down tissue.

How Stress Promotes Weight Gain

Cortisol stimulates fat and carbohydrate metabolism for fast energy (the fight-or-flight response), thereby stimulating insulin release to keep pace with the rising blood sugar levels. This results in an increase in our appetite. If we experience chronic stress, with chronically high levels of cortisol, we may end up hungry all the time, causing us to overeat.


Cortisol also influences where that weight will be deposited. A fascinating study on the effects of the release of cortisol during acute and chronic stress in non-overweight women was published in the journal Psychosomatic Medicine in 2001. The study clearly demonstrated that excess cortisol contributes to the deposition of visceral fat, particularly in the abdominal region. As we know, there are two types of fat: subcutaneous (under the skin) and visceral (found in the abdomen and surrounding our vital organs).


Central obesity sets the stage for a host of health concerns such as heart disease, strokes, and diabetes. Because of its serious threat to health, this has also been referred to as “toxic fat.” Traditionally, women worried about the size of their hips. However, when it comes to overall weight gain, it is preferable to have it on the hips as opposed to the stomach area—if not from an aesthetic point of view, then from a health point of view. Studies indicate that women (and men) who store their weight in the abdominal area have higher cortisol levels and higher stress levels than those whose weight is stored on the hips.


Visceral fat is metabolized by the liver, which turns it into cholesterol that circulates in the blood. This is the so-called “bad” cholesterol, low-density lipoprotein or LDL, which collects in the arteries forming plaque (deposits of fats, inflammatory cells, proteins, and calcium material along the lining of arteries). The plaque builds up and narrows the artery, resulting in atherosclerosis. Researchers have also found that consuming a lot of saturated fats such as butter and the fats found in red meats can lead to the accumulation of visceral fat. The high omega-3 content found in wild Alaskan salmon, anchovies, sardines, and other cold-water fish, along with fish oil capsules, will help you to get rid of this deadly form of fat because the essential fatty acids found in these foods can decrease cortisol levels.”


There is plenty of research to show the connection/link of excess cortisol levels and fat.
To sum up, elevated cortisol levels produce a host of negative effects that include:


  • increased inflammation
  • increased insulin secretion
  • increased appetite
  • storage of fat, particularly in the abdomen
  • Increased risk of acne flare-ups.
  • Acne is a systemic inflammatory disease and stress precipitates and aggravates acne breakouts.
  • The death of brain cells. High levels of stress actually shrink the brain and other organs.
  • destruction of the immune system
  • decreased muscle mass
  • Accelerated aging.

Key Ingredients in CortiSLIM

Although the new, advanced CortiSLIM has over a dozen ingredients all designed to increase energy, nourish the body and help support normal cortisol levels thereby helping to reduce excess body fat, here are just two ingredients found in CortiSLIM and their known health benefits:


Chromium is a critical nutrient in our effort to control and reduce excess body fat. By supplementing our diets with chromium, we can effectively lower blood sugar and insulin levels; the key to an anti-inflammatory weight-loss diet. One reason people are overweight is because they’re in an inflammatory state that has put a “lock” on their fat-burning mechanism. Chromium helps decrease inflammation, thereby unlocking the enzymes that aid in fat metabolization.

Chromium not only affects blood sugar and insulin levels, it can also help normalize blood lipids such as triglycerides and cholesterol, increasing levels of the HDL “good” cholesterol and lowering total cholesterol and triglycerides, making it cardio-protective.
Experts in the field of nutrition report that the general population of the United States is deficient in chromium and low levels of chromium are associated with type II diabetes and cardiovascular disease. Studies have also been published noting that increasedconsumption of sugar depletes our body stores of chromium, placing us at further risk for hyperglycemia and hyperinsulinemia (too much blood sugar, too much insulin).

Chromium Tips

  • Chromium is an essential nutrient required for normal sugar and fat metabolism.
  • Chromium is important for energy production, and also plays a key role in regulating appetite, reducing sugar cravings, and lowering body fat.
  • Chromium absorption is made more difficult when milk, as well as foods high in phosphorus, are eaten at the same time.
  • Don’t take chromium with foods rich in phytic acid (unleavened bread, raw beans, seeds, nuts, grains, and soy isolates) as this may decrease its absorption.
  • The recommended type of this supplement is chromium polynicotinate which is found in CortiSLIM.

Alpha Lipoic Acid

Alpha Lipoic Acid is a potent antioxidant and anti-inflammatory. It is found naturally in the body, locked inside the mitochondria. Lipoic acid is part of an enzyme complex called the pyruvate dehydrogenase complex, making it intimately involved in the energy production of the cell. Alpha Lipoic Acid enhances our ability to metabolize food into energy.

Unlike many other antioxidants such as vitamin C, which is strictly water soluble, or vitamin E, which is strictly fat soluble, Alpha Lipoic Acid is soluble in both water and fat. This means that Alpha Lipoic Acid can go to all parts of the cell, including the lipid (fat) portions such as the cell plasma membrane, as well as the interior of the cell (known as the cytoplasm) where water-soluble chemicals reside. Because of this unique property, alpha lipoic acid is often referred to as “the universal antioxidant.”

On a cellular level, Alpha Lipoic Acid exerts a wide variety of positive actions, all of them anti-inflammatory. It also blocks the activation of transcription factor NfkB as well, if not better than, any other antioxidant/anti-inflammatory thus far discovered.

In addition to its function as a powerful antioxidant/anti-inflammatory, Alpha Lipoic Acid increases the body’s ability to take glucose into the cells. This insulin-sensitizing effect is also seen in some of the other nutrients that we have discussed. These nutrients all work synergistically to increase sensitivity to insulin, resulting in decreased blood sugar levels. Alpha Lipoic Acid is also very powerful in preventing glycation.

Alpha Lipoic Acid Tips

  • In the metabolic cycle, Alpha Lipoic Acid acts as a coenzyme in the production of energy by converting carbohydrates into energy (ATP).
  • Alpha Lipoic Acid is the only antioxidant that can boost cellular levels of glutathione, the body’s most important antioxidant to overall health and longevity.

Dr. Legome took 40 overweight, stressed out patients and using saliva cortisol levels; proved cortisol levels were reduced along with weight reduction; fat loss and a reduction in excess insulin levels. Simply, by taking CortiSLIM; his patients reduced body fat, specifically “belly” fat and reduced their anxiety and other stress indicators.
Comparing synephrine found in bitter orange peel to ephedra, as if ephedra is dangerous because our illustrious FDA banned it.

What is Ephedra?

In China, Ephedra has been used over 2000 years in herbal medicine to treat bronchial asthma, the cold, flu, wheezing, and edema. Plants were and still are collected in autumn, sun-dried, and sectioned. Before use, the sections are boiled, often in a honey-water mixture, and usually further roasted until the water is evaporated. The bitter remedy resulting is prescribed for typhoid, colds, coughing, and various pains.
The dried stems of the species Ephedra geradiana have long been used in Northern India and Pakistan to relieve bronchial asthma. This species is believed to contain the same adrenergic drug similar to ephedrine, which is extracted from other species of the Ephedracea, and used as a bronchodilator in orthodox medicine.
Stem decoctions of Ephedra antisyphilitica in West Texas and Northern Mexico were used to cure renal diseases of the Southwestern American Indians. The seeds of E. nevadensis were also used to alleviate urogenital diseases; the medicine was prepared by roasting and then grinding the seeds into flour.
Like coffee and tea, Ephedra has also been brewed into a beverage and consumed for its stimulant effects. Ma huang extract, from Ephedra sinica and E. equisetina, is made by the same process as instant coffee, and similarly concentrated, with about three times the alkaloid as Ephedra herb.
Mormon tea (Desert tea, Teamster tea) was a very popular stimulant beverage made by the early settlers in the Southwestern United States and Mexico, brewed from the branches of Ephedra trifurca.

FDA Ban of Ephedra

As herbs continue to be in direct competition with the pharmaceutical cartels for every consumer dollar, it was alleged that three people died after a heat stroke and taking an herbal remedy with ephedra in it. There was never any proof ephedra had anything to do with heat stroke. The FDA was under orders to “get rid of ephedra, proof or no proof.”

There are over 486,000 known deaths per year from smoking tobacco. The FDA not only does nothing about it, our government subsidizes the tobacco industry! Ephedra was banned for political and economic reasons. This effective herb is still used throughout the world with little to no adverse effects. So what is synephrine?


Synephrine is an alkaloid found in fruits and vegetables, specifically in Bitter Oranges. An alkaloid is a pharmacologically active class of nitrogen-containing chemical compounds. The confusion many so-called “researchers” have concerning synephrine is not understanding the P form; Para verses the ‘M’ form or Meta. Bitter Orange contains the P form which has only been associated with ONE ADVERSE EVENT out of hundreds of years of use throughout the world.

For a more comprehensive understanding of synephrine, please go to the 28 page article written by Mark Blumenthal, founder and executive director of the American Botanical Council, Bitter Orange Peel and Synephrine

The bottom line is neither ephedra nor synephrine are dangerous when taken within safe limits established by hundreds of years of use. Even though a fresh bitter orange contains 270 mg of synephrine per 4 ounces, CortiSLIM contains only 20 mg of synephrine (Bitter Orange Peel) per capsule.

You can reduce cortisol by reducing stress and through a relaxing massage, a walk in the woods, meditating, bike ride, swimming or other activity. As far as being cheaper “than any pricy pill, powder, or capsule marketed”, one massage will pay for a three months’ supply of CortiSLIM. If you are like most people, you can not always eat properly, exercise or even de-stress. For those that need a little help, CortiSLIM seems to be the answer. Try it for yourself and then decide.


Epel ES, McEwen B, Seeman T, et al. Stress and body shape: Stress-induced cortisol secretion is consistently greater among women with central fat. Psychosomatic Med. 2000 Sept; 62(5):623-32.

Gluck ME, Geliebter A, Lorence M. Cortisol stress response is positively correlated with central obesity in obese women with binge eating disorder (BED) before and after cognitive-behavioral treatment. Ann NY Acad Sci. 2004 Dec; 1032:202-7.

* The statements on this website have not been evaluated by the Food and Drug Administration. CortiSLIM's products are not intended to diagnose, treat, cure or prevent any disease. Results may vary for each person. CortiSLIM's products should be used in conjunction with diet and exercise.

This article was authored by Dr. James Chappell

Dr. James Chappell is a retired board certified chiropractic doctor, traditional naturopath, clinical nutritionist and medical herbalist. Since 1971, he has been an avid health researcher and educator specializing in incorporating natural healing protocols for chronic, severe and so-called “terminal” illnesses. As a clinician, he has consulted over 11,000 patients and spent over ten years as one of the "lot" doctors for Paramount, Universal, MGM and Burbank studios in Hollywood, California seeing actors, producers and directors. He is a best-selling author, A Promise Kept: One Son’s Quest for the Cause and Cure of Dis-ease, lecturer, key note speaker, TV and radio personality with 24 TV infomercials, Commissioner – Citizens Commission for Human Rights (CCHR), spokesperson for the Whole Wellness Club, nutraceutical, botanical and aquaceutical formulator, corporate medical consultant and president of Chappell Health Products.